Mullerian adenosarcoma of the uterine cervix with sarcomatous. Mullerian adenosarcoma of the cervix with sarcomatous overgrowth and. The prognosis of adenosarcoma greatly depends on stage and the presence of sarcomatous overgrowth. Adenosarcoma of the uterus is a rare tumor of the uterus that typically originates in the lining of the uterus endometrium. Mullerian adenosarcoma with sarcomatous overgrowth maso is a very rare variant of uterine sarcomas first described by clement. Cervical mullerian adenosarcoma with heterologous sarcomatous. The presence of heterologous sarcomatous components is associated with aggressive biological behavior. These tumors consist of a benignappearing epithelial component and a lowgrade sarcomatous component frequently resembling endometrial stromal sarcoma. To date approximately 37 cases of uterine adenosarcoma with sarcomatous overgrowth have been reported in the literature 5, 1215. Typical symptoms in affected individuals may include abnormal vaginal bleeding, an enlarged uterus, and tissue protruding. Mullerian adenosarcoma with sarcomatous overgrowth maso of the uterine cervix is an extremely rare variant of adenosarcoma of the genital tract associated with aggressive clinical course. This clinicopathologic study was undertaken to compare the treatment and survival of uterine adenosarcoma with sarcomatous overgrowth to that of uterine carcinosarcomas. Mullerian adenosarcoma with sarcomatous overgrowth maso is a very rare variant of uterine sarcomas first described by clement et al. Otherwise deep myometrial invasion, high grade cytomorphology and sarcomatous overgrowth predict a poor prognosis.
Mullerian adenosarcoma with sarcomatous overgrowth maso is a rare variant of uterine sarcomas, associated with postoperative recurrence. Typical symptoms in affected individuals may include abnormal vaginal bleeding, an enlarged uterus, and tissue protruding from the external os external. Mullerian adenosarcoma is characterized by an intimate admixture of benign but occasionally atypical endometrial glands and a sarcomatous. Mullerian adenosarcoma heterologous of uterine cervix with. Mullerian adenosarcoma with sarcomatous overgrowth maso is a very aggressive variant, associated with postoperative recurrence. Mullerian adenosarcomas of the uterine cervix with. Uterine adenosarcoma ua is a mixed tumor of the uterus consisting of a benign glandular epithelium and a malignant mesenchymal component, which was originally reported as mullerian adenosarcoma by clement and scully in 1974. Mullerian adenosarcoma of uterus with sarcomatous overgrowth. The term mullerian adenosarcoma with sarcomatous overgrowth maso was first used by clemant and scully 8 in 1989 for those tumours in which a pure sarcoma, similar to or of a higher grade than that of the underlying adenosarcoma accounts for atleast onequarter of the tumour after thorough histological sampling. Ua is a rare malignancy, which accounts for 8% of all uterine sarcomas and sarcomatous part occupies 25% of. Uterine adenosarcoma with sarcomatous overgrowth versus. Mullerian adenosarcoma with sarcomatous overgrowth was first described in 1989 and suggests that the cluster of adenosarcomas reported herein may be due in part to the current classification of. Advanced uterine adenosarcoma with sarcomatous overgrowth in. Treatment strategy for vaginal adenosarcoma has not been established yet.
Uterine mullerian adenosarcoma with sarcomatous overgrowth fatal. Mullerian adenosarcoma of the uterus with sarcomatous overgrowth. The tumor is classified as an adenosarcoma with sarcomatous overgrowth when at least 25% of the tumor is composed of pure sarcoma. The term mullerian adenosarcoma with sarcomatous overgrowth maso was first used by clemant and scully4 in 1989 for those tumours in which a pure sarcoma, similar to or of a higher grade than that of the underlying adenosarcoma accounts for atleast onequarter of the tumour after thorough histological sampling.
Mullerian adenosarcoma of the uterus with sarcomatous overgrowth following tamoxifen treatment for breast cancer. The difference between ms and maso is the pure high grade sarcoma features in maso. This type of tumor is characterized by both benign noncancerous and malignant components lowgrade sarcoma. Mullerian adenosarcoma of the uterus with sarcomatous. Uterine mullerian adenosarcoma with sarcomatous overgrowth. Mullerian adenosarcoma with sarcomatous overgrowth maso is a rare variant of uterine sarcomas, associated with postoperative recurrence, metastases and a fatal outcome.
Uterine adenosarcoma ua with sarcomatous overgrowth asso is a. Advanced uterine adenosarcoma with sarcomatous overgrowth. Mullerian adenosarcoma with sarcomatous overgrowth was first described in 1989 and suggests that the cluster of adenosarcomas reported herein may be due in. Adenosarcoma is frequently associated with a good outcome if confined to the endometrium. Mullerian adenosarcoma with sarcomatous overgrowth maso is a rare variant of uterine adenosarcoma, where the pure sarcoma is similar to or. Primary vaginal adenosarcoma with sarcomatous overgrowth. Adenosarcoma of the uterus genetic and rare diseases.
Cervical mullerian adenosarcomas with sarcomatous overgrowth are rare and. Management of uterine adenosarcomas with and without. Uterine adenosarcoma with sarcomatous overgrowth asso is a rare variant of uterine sarcoma first described in 1989. Mullerian adenosarcomas are rare mixed mesenchymal and epithelial neoplasms usually arising from the uterus. Pdf mullerian adenosarcoma with sarcomatous overgrowth maso is a rare variant of uterine sarcomas, associated with postoperative recurrence. In the case of mullerian adenosarcoma, the presence of sarcomatous overgrowth should be strictly checked because of the difference in prognosis. A 37yearold nullipara presented with irregular vaginal bleeding, a normal pelvic examination, and an initially negative ultrasound.
494 1183 1007 379 186 957 1040 1352 113 1059 482 420 1039 411 195 1303 260 1055 78 881 193 209 1295 1452 886 1153 1567 1357 287 1580 491 190 700 609 1265 987 1425 1272 1190 328 529 1266 528